Application of Transexamic Acid in Total Hip Arthroplasty: Review of Current Concepts

Abstract

The purpose of this study was to assess the current concepts of the application of transexamic acid (TXA) in total hip arthroplasty. Perioperative blood loss in patients who undergo hip arthroplasty is a serious problem. Most patients are old and their cardiovascular system cannot easily tolerate hypovolemia. A literature review of 25 papers on TXA use in hip arthroplasty, to assess efficacy and cost-effectiveness of TXA, as well as the risk of thrombotic events may be useful. Our literature review is based on searching TXA and hip arthroplasty related articles in PubMed, Scopus, and Google Scholar. We focused on large meta-analysis articles and randomized clinical trials. Current concepts recommend routine application of TXA in hip arthroplasty, if no contraindications exist.