Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 2 4 2016 12 10 53 53 Adel Ebrahimpour Associated Professor of Orthopedic Surgery, Taleghani Hospital, Shahid Beheshti Medical University of Sciences, Tehran, Iran Mehrdad Sadighi Assistant Professor of Orthopedic Surgery, Taleghani Hospital, Shahid Beheshti Medical University of Sciences, Tehran, Iran Mohsen Karami Associated Professor of Orthopedic Surgery, Taleghani Hospital, Shahid Beheshti Medical University of Sciences, Tehran, Iran Mohammad Reza Minator Sajadi Assistant Professor of Orthopedic Surgery, Taleghani Hospital, Shahid Beheshti Medical University of Sciences, Tehran, Iran Reza Zandi Assistant Professor of Orthopedic Surgery, Taleghani Hospital, Shahid Beheshti Medical University of Sciences, Tehran, Iran Amin Karimi Assistant Professor of Orthopedic Surgery, Taleghani Hospital, Shahid Beheshti Medical University of Sciences, Tehran, Iran 2019 07 18 The purpose of this study was to assess the current concepts of the application of transexamic acid (TXA) in total hip arthroplasty. Perioperative blood loss in patients who undergo hip arthroplasty is a serious problem. Most patients are old and their cardiovascular system cannot easily tolerate hypovolemia. A literature review of 25 papers on TXA use in hip arthroplasty, to assess efficacy and cost-effectiveness of TXA, as well as the risk of thrombotic events may be useful. Our literature review is based on searching TXA and hip arthroplasty related articles in PubMed, Scopus, and Google Scholar. We focused on large meta-analysis articles and randomized clinical trials. Current concepts recommend routine application of TXA in hip arthroplasty, if no contraindications exist. https://jost.tums.ac.ir/index.php/jost/article/view/53 https://jost.tums.ac.ir/index.php/jost/article/download/53/53