An Introduction to Tissue Engineering and Orthopedic Applications
Abstract
Nowadays, orthopedic-related pathologic conditions are considered as a growing concern. Also, the conventional treatments (grafting techniques) are not efficacious enough for the growing clinical needs. In the last decades, researches have been focused on finding more effective alternative treatments. Tissue engineering (TE) is a newly emerging field of science that has great potential to reduce these clinical issues. There are three main components in TE including cells, biomaterials, and signals. Choosing the best combination of these components is a vital decision in a TE process. In this review article, we are going to discuss TE and its components and also highlight some of the researches in the field of orthopedic TE by focusing on some tissues including bone, cartilage, skin, skeletal muscle, peripheral nervous system (PNS), tendon, and ligament. In the end, TE, as a new field of science, faces some major challenges that we will address some of them in this article.
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3. Atala A. Tissue engineering and regenerative medicine: concepts for clinical application. Rejuvenation Res. 2004;7(1):15-31. doi: 10.1089/154916804323105053. [PubMed: 15256042].
4. Mao AS, Mooney DJ. Regenerative medicine: Current therapies and future directions. Proc Natl Acad Sci U S A. 2015;112(47):14452-9. doi: 10.1073/pnas.1508520112. [PubMed: 26598661]. [PubMed Central: PMC4664309].
5. Wyles SP, Hayden RE, Meyer FB, Terzic A. Regenerative medicine curriculum for next-generation physicians. NPJ Regen Med. 2019;4:3. doi: 10.1038/s41536-019-0065-8. [PubMed: 30774984]. [PubMed Central: PMC6367326].
6. Eltom A, Zhong G, Muhammad A. Scaffold techniques and designs in tissue engineering functions and purposes: A review. Advances in Materials Science and Engineering. 2019;2019.
7. Nerem RM. Tissue engineering in the USA. Med Biol Eng Comput. 1992;30(4):CE8-12. doi: 10.1007/BF02446171. [PubMed: 1487936].
8. Howard D, Buttery LD, Shakesheff KM, Roberts SJ. Tissue engineering: strategies, stem cells and scaffolds. J Anat.
2008;213(1):66-72.doi:10.1111/j.1469-7580.2008.00878.x.
[PubMed: 18422523]. [PubMed Central: PMC2475566].
9. Murphy CM, O'Brien FJ, Little DG, Schindeler A. Cell-scaffold interactions in the bone tissue engineering triad. Eur Cell Mater. 2013;26:120-32. doi: 10.22203/ecm.v026a09. [PubMed: 24052425].
10. Sipe JD. Tissue engineering and reparative medicine. Ann N Y Acad Sci. 2002;961:1-9. doi: 10.1111/j.1749-6632.2002.tb03040.x. [PubMed: 12081856].
11. Pereira H, Cengiz F, Silva-Correia J, Oliveira M, Reis RL, Espregueira-Mendes J. Human Meniscus: From biology to tissue engineering strategies. In: Hutson M, Speed C, Editors. Sports injuries. Berlin, Germany: Springer; 2015. p. 1089-102.
12. Tatara AM, Mikos AG. Tissue engineering in orthopaedics. J BoneJointSurgAm.2016;98(13):1132-9.doi:10.2106/JBJS.16.00299. [PubMed: 27385687]. [PubMed Central: PMC4928040].
13. Dzobo K, Thomford NE, Senthebane DA, Shipanga H, Rowe A, Dandara C, et al. Advances in regenerative medicine and tissue engineering: innovation and transformation of medicine. Stem Cells Int. 2018;2018:2495848. doi: 10.1155/2018/2495848. [PubMed: 30154861]. [PubMed Central: PMC6091336].
14. Bean AC, Huard J. Tissue engineering applications in orthopedic surgery. In: Meyer U, Meyer T, Handschel J, Wiesmann HP, Editors. Fundamentals of tissue engineering and regenerative medicine. Berlin, Germany: Springer Science & Business Media; 2009. p. 913-9.
15. Laurencin CT, Ambrosio AM, Borden MD, Cooper JA Jr. Tissue engineering: orthopedic applications. Annu Rev Biomed Eng. 1999;1:19-46. doi: 10.1146/annurev.bioeng.1.1.19. [PubMed: 11701481].
16. Cengiz IF, Pereira H, de GL, Cucchiarini M, Espregueira-Mendes J, Reis RL, et al. Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room. J Exp Orthop. 2018;5(1):14. doi: 10.1186/s40634-018-0133-9. [PubMed: 29790042]. [PubMed Central: PMC5964057].
17. Alexander PG, Hofer HR, Clark KL. Mesenchymal stem cells in musculoskeletal tissue engineering. In: Lanza R, Langer R, Vacanti JP, Editors. Principles of tissue engineering. Cambridge, MA: Academic Press; 2014. p. 1171-99.
18. Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng. 2012;40(5):363-408. doi: 10.1615/critrevbiomedeng.v40.i5.10. [PubMed: 23339648]. [PubMed Central: PMC3766369].
19. Shrivats AR, McDermott MC, Hollinger JO. Bone tissue engineering: state of the union. Drug Discov Today. 2014;19(6):781-6. doi: 10.1016/j.drudis.2014.04.010. [PubMed: 24768619].
20. Sheikh Z, Najeeb S, Khurshid Z, Verma V, Rashid H, Glogauer M. Biodegradable Materials for Bone Repair and Tissue Engineering Applications. Materials (Basel). 2015;8(9):5744-94. doi: 10.3390/ma8095273. [PubMed: 28793533]. [PubMed Central: PMC5512653].
21. Travnickova M, Bacakova L. Application of adult mesenchymal stem cells in bone and vascular tissue engineering. Physiol Res. 2018;67(6):831-50. doi: 10.33549/physiolres.933820. [PubMed: 30204468].
22. Mishra R, Bishop T, Valerio IL, Fisher JP, Dean D. The potential impact of bone tissue engineering in the clinic. Regen Med. 2016;11(6):571-87. doi: 10.2217/rme-2016-0042. [PubMed: 27549369]. [PubMed Central: PMC5007661].
23. Wubneh A, Tsekoura EK, Ayranci C, Uludag H. Current state of fabrication technologies and materials for bone tissue
engineering. Acta Biomater. 2018;80:1-30. doi:
10.1016/j.actbio.2018.09.031. [PubMed:
30248515].
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| Files | ||
| Issue | Vol 6, No 1 (2020) | |
| Section | Review Article | |
| DOI | https://doi.org/10.18502/jost.v6i1.4534 | |
| Keywords | ||
| Tissue Engineering; Orthopedic; Cell Engineering; Bioengineering; Tissue Therapy | ||
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How to Cite
1.
Baghaie Nia F, Khavari F, Firouzi M, Nabian MH. An Introduction to Tissue Engineering and Orthopedic Applications. J Orthop Spine Trauma. 2020;6(1):1-8.
