Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 12 1 2026 03 06 1 4 EN Reza Yousefvand MD Candidate, Center for Orthopedic Trans-Disciplinary Applied Research, Tehran University of Medical Sciences, Tehran, Iran Javad Moeini Spine Surgery Fellowship, Department of Orthopedic Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2025 07 17 2026 01 26 Kyphoplasty is a minimally invasive procedure primarily used for the treatment of osteoporotic vertebral compression fractures, traumatic fractures, and spinal involvement due to metastatic cancer. Even though kyphoplasty is generally regarded as a safe intervention, physicians should be aware of its potentially serious complications, even though they are rare, especially considering the high number of patients who have the procedure done each year. This study aims to review the most significant complications related to kyphoplasty, along with their incidence, risk factors, preventive strategies, and management approaches. We reviewed relevant articles from PubMed, Google Scholar, and credible sources to write this assay. There are several ways that cement leakage can occur, including paravertebral (the most common), epidural, intradiscal, pulmonary embolism, and foraminal leakage. It has been demonstrated that the eggshell technique, directional balloon placement, high-viscosity cement, and smaller cement volumes all lower the chance of cement leakage. Two important risk factors for adjacent vertebral fractures are intradiscal cement leakage and preexisting osteoporosis in nearby vertebrae. Thus, managing these two elements could help avoid this issue. Achieving the best therapeutic results requires understanding the potential side effects of kyphoplasty and implementing effective management and prevention techniques. https://jost.tums.ac.ir/index.php/jost/article/view/692 https://jost.tums.ac.ir/index.php/jost/article/download/692/454