Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 11 2 2025 06 15 81 5 Reza Moulaei Department of Orthopedic and trauma surgery, Shariati hospital, Tehran university of medical sciences, Tehran, Iran Khadijeh Moulaei Health Management and Economics Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran Fardis Vosoughi Department of Orthopedic and trauma surgery, Shariati hospital, Tehran university of medical sciences, Tehran, Iran 2024 12 26 2025 05 31 Background: The Morel-Lavallée lesion (MLL) is an unusual injury that occurs due to shearing forces separating the skin from the underlying layers. This lesion can lead to an infectious hematoma and create a life-threatening condition. Case report: A case of a 21-year-old female patient is presented who visited the emergency department after a truck ran over her foot. It was later determined that she had an MLL in her thigh. The patient fully recovered using a vacuum-assisted closure. Conclusion: It is crucial for orthopedic surgeons to be aware of the diagnostic steps and symptoms to quickly identify and treat MLL before it causes irreversible damage to the patient. https://jost.tums.ac.ir/index.php/jost/article/view/649 https://jost.tums.ac.ir/index.php/jost/article/download/649/414