Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 11 2 2025 06 15 45 9 Shantanu Vijay Junior Resident, GMERS Medical College, Gotri, Vadodara, Gujarat, India Subham Verma Senior Resident, GMERS Medical College, Gotri, Vadodara, Gujarat, India Bharat Soni Senior Resident, GMERS Medical College, Gotri, Vadodara, Gujarat, India Tarun Desai Associate Professor, GMERS Medical College, Gotri, Vadodara, Gujarat, India Prashant Alwani Associate Professor, GMERS Medical College, Gotri, Vadodara, Gujarat, India Jeevan Appala Junior Resident, GMERS Medical College, Gotri, Vadodara, Gujarat, India Chirag Thakkar Professor, GMERS Medical College, Gotri, Vadodara, Gujarat, India 2024 09 02 2025 04 26 Background: Using tranexamic acid (TXA) as a measure to ensure hemostasis during surgeries involving the hip region is a topic that is still debated, with scarce literature. The aim of this study was to assess the effectiveness of TXA administration in improving outcomes of hip arthroplasty. Methods: This is a randomized comparative prospective study. It was conducted in the Department of Orthopedics, GMERS Medical College and Hospital, Vadodara, India, from January 2023 to December 2023 on 60 patients undergoing hip arthroplasty. Results: The postoperative mean hemoglobin (Hb) value after 24 hours in the test group was 10.9 ± 1.6 g/dl while it was 10.1 ± 1.4 in the control group, which was statistically significant. The mean duration of surgery in the test group was 102.7 ± 28.2 minutes versus  125.2 ± 36.5 minutes in control with a P-value of 0.01, indicating less surgical duration in the test group. Conclusion: TXA is an effective agent to reduce intraoperative blood loss, reduce surgical time, and improve post-operative Hb levels. https://jost.tums.ac.ir/index.php/jost/article/view/624 https://jost.tums.ac.ir/index.php/jost/article/download/624/406