Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 10 1 2024 04 01 15 18 Seyd Houssein Saeed-Bandaky 0000-0002-6481-0227 Maziar Malekzadeh 0000000188666584 Abbas Tafti Trauma Research enter, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2023 01 10 2024 04 01 Background: Surgical site hematoma is one of the factors that influences the results of the carpal tunnel release and patients’ satisfaction ; therefore, this study was designed to evaluate the effects of using Penrose drain in order to reduce the operation site hematoma and improve the results of surgery. Methods: Patients with a diagnosis of carpal tunnel syndrome (CTS) were randomly divided into intervention and control group and then were evaluated by pain with Visual Analog Scale (VAS) and Pinch power. Penrose drain was placed for the intervention group and removed after two days. Three months after surgery, all patients were re-evaluated by VAS and pinch power, and then the collected data were analyzed statistically using the Wilcoxon Signed Ranks Test by SPSS. Results: Out of 46 patients, Penrose drain was placed for 21 patients. According to the results, the VAS and Pinch power evaluations were better in patients with Penrose drain (P-value = 0.001) but in patients without Penrose drain, only the VAS evaluation results were improved, but a decrease in Pinch powers was detected. Conclusion: The results showed that CTR surgery with or without the Penrose drain decreases pain in patients after three months of operation. CTR with Penrose drain improve Pinch power and also decreases the pain, but in patients without Penrose drain, Pinch power was reduced after this period. https://jost.tums.ac.ir/index.php/jost/article/view/464 https://jost.tums.ac.ir/index.php/jost/article/download/464/361