Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 9 2 2023 08 03 46 52 Mohammad Ayati Firoozabadi Department of Orthopedic Surgery, Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Behzad Nezhad Tabrizi Department of Orthopedic Surgery, Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Seyed Mohammad Milad Seyed Tabaei Department of Orthopedic Surgery, Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Alireza Moharrami Department of Orthopedic Surgery, Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran SM Javad Mortazavi Department of Orthopedic Surgery, Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2022 05 30 2023 08 03 Arthroscopy procedures for the knee are excellent and tend to be outpatient procedures. Pain control after arthroscopic surgery is an important aspect of patient satisfaction and quicker return to daily activities following surgery. The objective of this article was to review the current literature regarding pain management after knee arthroscopy using intra-articular (IA) injections. Our goal in this article is to review the drugs that have been suggested in various articles for IA injections following knee arthroscopy to control pain. In conclusion, the current evidence suggests that combining IA lidocaine and morphine with tranexamic acid (TXA), in addition to ketorolac, is effective for pain relief after arthroscopic knee surgery. https://jost.tums.ac.ir/index.php/jost/article/view/400 https://jost.tums.ac.ir/index.php/jost/article/download/400/312