Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 9 3 2023 10 10 107 9 Mohammadreza Salehi Department of Infectious Diseases, Imam Khomeini Hospital complex, Tehran University of Medical Sciences Leila Seddigh Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences Sahar Shafagh Department of Infectious Diseases, Research Center for Antibiotic Stewardship and Anti-Microbial Resistance, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Behshad Pazooki   Department of Internal Medicine, Imam Khomeini Hospital complex, Tehran University of Medical Sciences Minoo Sadat Hajmiri Department of Internal Medicine, Imam Khomeini Hospital complex, Tehran University of Medical Sciences Banafsheh Moradmand-Badie   Black Dog Institute (BDI), University of New South Wales (UNSW), Sydney, Australia Nasim Khajavi Rad Department of Internal Medicine, Imam Khomeini Hospital complex, Tehran University of Medical Sciences Seyed Ali Dehghan Manshadi Department of Infectious Diseases, Research Center for Antibiotic Stewardship and Anti-Microbial Resistance, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Nima Bagheri     Department of Orthopedics, Imam Khomeini Hospital, Tehran University of Medical Sciences Mehrnaz Rasolinejad Department of Infectious Diseases, Research Center for Antibiotic Stewardship and Anti-Microbial Resistance, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Seyed Mahmoud Sajadi Jazi Department of Internal Medicine, Endocrinology & Metabolism ward, Shariati Hospital, Tehran University of Medical Sciences 2021 11 09 2022 02 26 Background: The diabetic foot is a chronic complication of diabetes. There is a strong relationship between glucose levels, the severity of diabetic foot ulcers (DFUs), and the need for amputation. This study aimed to evaluate the blood sugar (BS) trends before and after surgery in patients with DFU who had been amputated. Methods: The adult patients who had undergone DFU-related amputation surgery between 2017 and 2020 in Imam Khomeini Hospital Complex, Tehran, Iran, were evaluated. The cases whose BS levels were charted at least three days before and after amputation were recruited. The main data, including hypoglycemia (defined as a blood glucose level < 70 mg/dl) and mean BS and fasting BS (FBS) levels, were recorded. The data were then analyzed and compared before and after amputation. Results: Of 267 patients reviewed for inclusion criteria, 55 patients were included in the study. Twenty-eight patients (50.9%) were men, and the mean age was 60 years. The mean FBS before and after amputation was 229.5 and 181.3 mg/dl, respectively, and the mean BS before and after amputation was 227.3 and 197.8 mg/dl, respectively. The differences were significant (P < 0.001). Twelve patients (21.8%) before and 21 patients (36.4%) after amputation suffered from hypoglycemia (P = 0.057). Conclusion: DFU-related amputation is associated with a significant decrease in blood glucose levels and inflammatory indexes. However, it can increase the risk of hypoglycemia during the first three days after the surgery. https://jost.tums.ac.ir/index.php/jost/article/view/334 https://jost.tums.ac.ir/index.php/jost/article/download/334/322