Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 8 1 2022 04 13 5 8 Ehsan Fallah Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Alireza Moharrami Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Amir Hossein Ahmadi Nouri School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Mir Mansour Moazen Jamshidi Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Amir Reza Mafi Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran SM Javad Mortazavi Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2021 10 03 2022 01 06 Total Joint Arthroplasty (TJA) is a major surgery performed for patients who suffer from severe joint destruction. It is so important to reduce the blood loss in the TJA surgery to decrease the infection rate, falling, and other complications following the surgery. Many methods could reduce blood loss, such as mechanical methods and chemical methods. Tranexamic acid (TXA) is a chemical method to reduce blood loss in surgery. There are numerous methods of administration of TXA in the literature, such as intravenous (IV), intra-articular, and a combination of intra-articular and -venous methods. In the present review article, we review the studies that compared the efficacy of each method of the TXA administration.   https://jost.tums.ac.ir/index.php/jost/article/view/319 https://jost.tums.ac.ir/index.php/jost/article/download/319/252