Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 6 2 2021 01 19 30 32 Seyed Hadi Kalantar Department of Orthopedic Surgery, Joint Reconstruction Research Center, Tehran University of Medical Sciences SM Javad Mortazavi Department of Orthopedic Surgery, Joint Reconstruction Research Center, Tehran University of Medical Sciences Nima Bagheri Department of Orthopedic Surgery, Joint Reconstruction Research Center, Tehran University of Medical Sciences Seyed Ali Dehghan Manshadi Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Alireza Moharrami Department of Orthopedic Surgery, Joint Reconstruction Research Center, Tehran University of Medical Sciences Parastoo Ariamloo Imam Khomeini Complex Hospital, Tehran University of Medical Sciences Esmaeil MohammadNejad Imam Khomeini Complex Hospital, Tehran University of Medical Sciences Sheila Rasta Department of Orthopedic Surgery, Joint Reconstruction Research Center, Tehran University of Medical Sciences 2020 09 17 2021 01 19 Background: The novel coronavirus disease-2019 (COVID-19) has become a significant worldwide problem since January 2019. Hospitals have spent most of their time and logistics on patients with COVID-19. During this crisis, many healthcare providers have been infected with the disease, and occasionally, some wards and operating rooms were shut down as a result. Here, we explain our experience with the healthcare staff involvement with COVID-19 in our hospital.   Methods: As a referral tertiary center, Imam Khomeini Hospital (Tehran, Iran) has 4,200 health-care workers (HCWs). From February 20, 2020 to August 21, 2020, we investigated the hospital database for COVID-19 involvement among the staff.   Results: During the study period, 973 (23%) hospital HCWs were detected with COVID-19, 378 (9%) of whom were involved between June 21 and July 21, 2020. In the orthopedic department, 20 of 43 (46%) HCWs were infected with COVID-19.   Conclusion: We believe that the increase in the incidence of the disease and higher risk of exposure is a highly noticeable factor which should be addressed by the administrative health officials. https://jost.tums.ac.ir/index.php/jost/article/view/215 https://jost.tums.ac.ir/index.php/jost/article/download/215/196