Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 6 1 2020 11 15 22 3 Amir Sabbaghzadeh Department of Orthopedics, Bone, Joint and Related Tissue Research Center, Akhtar Orthopedic Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hossein Mohebi Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shiva Momen School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Morteza Gholipour Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Seyyed-Mohsen Hosseininejad Bone, Joint and Related Tissue Research Center(BJRTrc), Shahid Beheshti University of Medical Sciences, Tehran, Iran 2020 07 02 2020 08 08 Background: Freiberg’s disease is an uncommon condition typified by bony infarction of the second metatarsal head with a vague multifactorial etiology which tends to mostly occur in women. Case Report: A 22-year-old woman presented with second metatarsal head local pain exacerbating while walking without any prominent previous trauma history; clinical and imaging workups revealed metatarsal head osteonecrosis of Freiberg’s infarction. Conclusion: It should be kept in mind that for those complaining of forefoot discomfort, especially in the region of metatarsal heads, Freiberg’s avascular necrosis (AVN) could be a potential pathology. https://jost.tums.ac.ir/index.php/jost/article/view/194 https://jost.tums.ac.ir/index.php/jost/article/download/194/176