Tehran University of Medical Sciences Journal of Orthopedic and Spine Trauma 2538-2330 4 2 2020 05 05 23 25 EN Mohammad Reza Minator Sajjadi Assistant Professor, Taleghani Hospital Research Development Committee, Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Reza Zandi Assistant Professor, Taleghani Hospital Research Development Committee, Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Ali Okhovatpour Assistant Professor, Taleghani Hospital Research Development Committee, Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Pooyan Jalalpour Resident of Orthopedics, Taleghani Hospital Research Development Committee,Department of Orthopedics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Reza Moshari Assistant Professor, Department of Anesthesiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2019 10 29 2020 01 14 Background: In different ways, drugs are administered to reduce postoperative analgesia after arthroscopic anterior cruciate ligament (ACL) reconstruction. The purpose of this study is to compare the dexmedetomidine (DEX) intra-articular injection with bupivacaine hydrochloride and sterile 0.9% saline administration following arthroscopic ACL reconstruction. Methods: Sixty cases who underwent ACL reconstruction were randomly divided into three groups. The first group received intra-articular DEX; the second group received intra-articular bupivacaine, and the final group received intra-articular 0.9% saline. Postoperative pain was measured by the Visual Analogue Scale (VAS). Results: The mean VAS scores at 6 and 24 hours after surgery were lower in the bupivacaine group, compared to the other groups. The pain was more severe in the control group (0.9% saline), with higher VAS scores reported at 1, 6, and 24 hours after surgery. Conclusions:  Bupivacaine has more significant effects than DEX in postoperative pain management after arthroscopic ACL reconstruction.   https://jost.tums.ac.ir/index.php/jost/article/view/123 https://jost.tums.ac.ir/index.php/jost/article/download/123/118