Management of Minimally Invasive Spine Surgery in Spinal Metastases: A Comprehensive Systematic Review and Meta-Analysis on Strategies, Treatments, and Outcomes
-
Daniel Antonio Encarnación-Santos
,
Gennady Chmutin
,
Egor Chmutin
,
Stepan A Kudryakov
,
Petr Baygushev
,
Renat Nurmukhametov
,
Medet Dosanov
,
Dilerbek Nuriddinov
,
Arstanbekov Beksultan
,
Nazmin Ahmed
,
Sultan Mujib Dabiry
,
Peter Magembe Mrimba
,
Bipin Chaurasia
Abstract
Background: Minimally invasive spine surgery (MISS) represents an effective and increasingly adopted treatment strategy for spinal metastases. Over one million Americans are diagnosed with spinal metastases each year, and just 1.5 million are reported to be diagnosed; only 40-70 percent are spinal metastases. More advanced current percutaneous treatments such as kyphoplasty and vertebroplasty have improved the status of patients previously ruled out for surgery. Osteoblastic and osteolytic spinal metastases can be assessed and treated with percutaneous microwave ablation.
Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The comprehensive search involved several databases, including ScienceDirect and PubMed/MEDLINE, and was performed using the PRISMA guidelines, R software, and Excel. Search terms included “minimally invasive approach in metastatic lesions of the spine and spinal cord” combined with terms specifying surgical techniques, rehabilitation methods, and associated pathologies. Only studies published in English from January 2012 to February 2025 were included.
Results: Our study was based on a comprehensive systematic review and meta-analysis of 2380 patients with spinal metastases who were treated with minimally invasive and traditional open approaches, specifically vertebroplasty and kyphoplasty. We found 1090 patients (46%) with spinal metastases, where 509 cases (21%) were treated with the minimally invasive approach (MISS), while the traditional open approach [traditional open surgery (TOS)] was used for 432 patients (18%). 1611 patients (67%) were intervened by the leves of the fractures. Affected levels, whose cement breaches were 752 patients (31%) with metastases and CSF leaking.
Conclusion: New concepts were also employed in the minimally invasive, open approach which began with minimally invasive procedures such as vertebroplasty and kyphoplasty, and proceeded to treatments like percutaneous microwave ablation. Simple radiation therapy and chemotherapy, including the use of second-generation bisphosphonates such as pamidronate, are recommended, as well as steroids such as dexamethasone and methylprednisolone.
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| Files | ||
| Issue | Vol 12 No 3 (2026) | |
| Section | Research Articles | |
| Keywords | ||
| Minimally Invasive Surgery Metastases Kyphoplasty Vertebroplasty | ||
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How to Cite
1.
Encarnación-Santos D, Chmutin G, Chmutin E, Kudryakov SA, Baygushev P, Nurmukhametov R, Dosanov M, Nuriddinov D, Beksultan A, Ahmed N, Mujib Dabiry S, Mrimba P, Chaurasia B. Management of Minimally Invasive Spine Surgery in Spinal Metastases: A Comprehensive Systematic Review and Meta-Analysis on Strategies, Treatments, and Outcomes. J Orthop Spine Trauma. 2026;12(3):119-30.
