Pseudomyxoma Peritonei Lesion of the Thoracic Spine: A Case Report and Literature Review
-
Hieu Kim Huynh
,
Maxime Lacroix
,
Pierre Guigui
,
Emmanuelle Ferrero
,
Tchao Meatchi
,
Marc Khalifé
Abstract
Background: Pseudomyxoma peritonei (PMP) is a rare condition, with no previously described location in the spine. Here is presented a case of PMP extension to the thorax and then the spine, treated with two-level vertebrectomy, laminectomy, and posterior fusion.
Case Report: We report here the case of a 64-year-old man presenting pathological fractures of T6 and T7 due to PMP extension to the pleural cavity and thoracic spine. He presented interscapular pain with mild spinal cord compression symptoms. He was treated by achieving T5-T8 laminectomy, T2-T10 pedicle fixation, and T6-T7 vertebrectomy. The postoperative course was uneventful apart from a pulmonary embolism (PE) with favorable evolution under anticoagulants.
Conclusion: To achieve spinal cord decompression, kyphosis correction, and spine stabilization, a two-level vertebrectomy, laminectomy, and posterior fusion would be beneficial for a PMP lesion of the thoracic spine.
1. Yu B, Raj MS. Pseudomyxoma peritonei. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2022.
2. O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH. Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells. Am J Pathol. 2002;161(2):551-64. doi: 10.1016/S0002- 9440(10)64211-3. [PubMed: 12163380]. [PubMed Central: PMC1850719].
3. Csanyi-Bastien M, Blanchard F, Lamy A, Sabourin JC. A case of Pseudomyxoma Peritonei of an unexpected origin. Diagn Pathol. 2021;16(1):119. doi: 10.1186/s13000-021-01179-z. [PubMed:34930348]. [PubMed Central: PMC8686532].
4.Moran BJ, Cecil TD. The etiology, clinical presentation, and management of pseudomyxoma peritonei. Surg Oncol Clin N Am. 2003;12(3):585-603. doi: 10.1016/s1055-3207(03)00026-7. [PubMed: 14567019].
5. Mittal R, Chandramohan A, Moran B. Pseudomyxoma peritonei: natural history and treatment. Int J Hyperthermia. 2017;33(5):511-9. doi: 10.1080/02656736.2017.1310938. [PubMed: 28540829].
6. Esquivel J, Sugarbaker PH. Clinical presentation of the J Orthop Spine Trauma. 2024; 10(3): 130-4.133
Huynh et al.: Thoracic Pseudomyxoma Peritonei https://jost.tums.ac.ir Pseudomyxoma peritonei syndrome. Br J Surg. 10.1046/j.1365-2168.2000.01553.x. 2000;87(10):1414-8. [PubMed: 11044169].
7. Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, et al. Pathology and prognosis in pseudomyxoma peritonei: A review of 274 cases. J Clin Pathol. 2012;65(10):919-23. doi: 10.1136/jclinpath-2012-200843. [PubMed: 22718846].
8. Lee BY, Kim HS, Lee SH, Moon HS, Cho SM, Lee KH, et al. Pseudomyxoma peritonei: Extraperitoneal spread to the pleural cavity and lung. J Thorac Imaging. 2004;19(2):123-6. doi: 10.1097/00005382-200404000-00013. [PubMed: 15071333].
9.Wambura C, Jusabani A, Sherman O, Surani S. Pseudomyxoma pleurii and peritonei secondary to sigmoid colon adenocarcinoma: A rare clinico-pathologico-radiological presentation. Oxf Med Case Reports. 2018;2018(10):omy057. doi: 10.1093/omcr/omy057. [PubMed: 30250743]. [PubMed Central: PMC6142713].
10. Khalifé M, Guigui P, Hoffmann E, Ferrero E. Techniques d'ostéotomie vertébrale. https://www em-consulte com/article/1418629/techniques-d-osteotomie-vertebrale. 2020; 20: 44-150. doi: 10.1016/S0246-0467(20)42625-X.
11. Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, Gonzalez-Moreno S, et al. A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: The results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process. Am J Surg Pathol. 2016;40(1):14-26. doi: 10.1097/PAS.0000000000000535. [PubMed: 26492181].
12. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA. Appendiceal neoplasms and pseudomyxoma peritonei: A population based study. Eur J Surg Oncol. 2008;34(2):196-201. doi: 10.1016/j.ejso.2007.04.002. [PubMed: 17524597].
13. Belhamidi MS, Zorkani Y, Krimou H, Kaoukabi A, Menfaa M, Sakit F, et al. Pseudomyxoma peritonei (PMP) secondary to mucinous carcinoma of the ovary: A case study. Pan Afr Med J. 2019;33:283. [In Persian]. doi: 10.11604/pamj.2019.33.283.17203. [PubMed: 31692896]. [PubMed Central: PMC6815498].
14. Ning S, Yang Y, Wang C, Luo F. Pseudomyxoma peritonei induced by low-grade appendiceal mucinous neoplasm accompanied by rectal cancer: A case report and literature review. BMC Surg. 2019;19(1):42. doi: 10.1186/s12893-019-0508-6. [PubMed: 31023277]. [PubMed Central: PMC6485155].
15. Prabhu RM, Koshire SR, Khandelwal RCS. A rare case of psoas abscess secondary to mucinous adenocarcinoma of the appendix: A case report. J Orthop Case Rep. 2021;11(8):1-5. doi: 10.13107/jocr.2021.v11.i08.2340. [PubMed: 35004364]. [PubMed Central: PMC8686507].
16. Ghosh RK, Somasundaram M, Ravakhah K, Hassan C. Pseudomyxoma peritonei with intrathoracic extension: A rare disease with rarer presentation from low-grade mucinous adenocarcinoma of the appendix. BMJ Case Rep. 2016;2016. doi: 10.1136/bcr-2015-211076. [PubMed: 26729823]. [PubMed Central: PMC4716424].
17. Youssef H, Newman C, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ. Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin. Dis Colon Rectum. 2011;54(3):293-9. doi: 10.1007/DCR.0b013e318202f026. [PubMed: 21304299].
18. McBride K, McFadden D, Osler T. Improved survival of patients with pseudomyxoma peritonei receiving intraperitoneal chemotherapy with cytoreductive surgery: a systematic review and meta-analysis. J Surg Res. 2013;183(1):246-52. doi: 10.1016/j.jss.2012.12.040. [PubMed: 23490141].
19. Baratti D, Kusamura S, Guaglio M, Milione M, Pietrantonio F, Cavalleri T, et al. Relapse of Pseudomyxoma peritonei after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Pattern of failure, clinical management and outcomes. Ann Surg Oncol. 2023;30(1):404-14. doi: 10.1245/s10434-022-12367-6. [PubMed: 36094689].
20. Proesmans V, Vandaele T, Van Slambrouck J, Wolthuis A, Hoore D, Dekervel J, et al. Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma. Int J Hyperthermia. 2022;39(1):1153-7. doi: 10.1080/02656736.2022.2104938. [PubMed: 36049823].
21. Pestieau SR, Esquivel J, Sugarbaker PH. Pleural extension of mucinous tumor in patients with pseudomyxoma peritonei syndrome. Ann Surg Oncol. 2000;7(3):199-203. doi: 10.1007/BF02523654. [PubMed: 10791850].
22. Sugarbaker PH, Chang D, Stuart OA. Hyperthermic intraoperative thoracoabdominal chemotherapy. Gastroenterol Res Pract. 2012;2012:623417. doi: 10.1155/2012/623417. [PubMed: 22654899]. [PubMed Central: PMC3357938].
23. Yahanda AT, Buchowski JM, Wegner AM. Treatment, complications, and outcomes of metastatic disease of the spine: From Patchell to PROMIS. Ann Transl Med. 2019;7(10):216. doi: 10.21037/atm.2019.04.83. [PubMed: 31297381]. [PubMed Central: PMC6595215].
24. Lau D, Deviren V, Ames CP. The impact of surgeon experience on perioperative complications and operative measures following thoracolumbar 3-column osteotomy for adult spinal deformity: overcoming the learning curve. J Neurosurg Spine. 2019;32(2):207-20. doi: 10.3171/2019.7.SPINE19656. [PubMed: 31653817].
2. O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH. Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells. Am J Pathol. 2002;161(2):551-64. doi: 10.1016/S0002- 9440(10)64211-3. [PubMed: 12163380]. [PubMed Central: PMC1850719].
3. Csanyi-Bastien M, Blanchard F, Lamy A, Sabourin JC. A case of Pseudomyxoma Peritonei of an unexpected origin. Diagn Pathol. 2021;16(1):119. doi: 10.1186/s13000-021-01179-z. [PubMed:34930348]. [PubMed Central: PMC8686532].
4.Moran BJ, Cecil TD. The etiology, clinical presentation, and management of pseudomyxoma peritonei. Surg Oncol Clin N Am. 2003;12(3):585-603. doi: 10.1016/s1055-3207(03)00026-7. [PubMed: 14567019].
5. Mittal R, Chandramohan A, Moran B. Pseudomyxoma peritonei: natural history and treatment. Int J Hyperthermia. 2017;33(5):511-9. doi: 10.1080/02656736.2017.1310938. [PubMed: 28540829].
6. Esquivel J, Sugarbaker PH. Clinical presentation of the J Orthop Spine Trauma. 2024; 10(3): 130-4.133
Huynh et al.: Thoracic Pseudomyxoma Peritonei https://jost.tums.ac.ir Pseudomyxoma peritonei syndrome. Br J Surg. 10.1046/j.1365-2168.2000.01553.x. 2000;87(10):1414-8. [PubMed: 11044169].
7. Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, et al. Pathology and prognosis in pseudomyxoma peritonei: A review of 274 cases. J Clin Pathol. 2012;65(10):919-23. doi: 10.1136/jclinpath-2012-200843. [PubMed: 22718846].
8. Lee BY, Kim HS, Lee SH, Moon HS, Cho SM, Lee KH, et al. Pseudomyxoma peritonei: Extraperitoneal spread to the pleural cavity and lung. J Thorac Imaging. 2004;19(2):123-6. doi: 10.1097/00005382-200404000-00013. [PubMed: 15071333].
9.Wambura C, Jusabani A, Sherman O, Surani S. Pseudomyxoma pleurii and peritonei secondary to sigmoid colon adenocarcinoma: A rare clinico-pathologico-radiological presentation. Oxf Med Case Reports. 2018;2018(10):omy057. doi: 10.1093/omcr/omy057. [PubMed: 30250743]. [PubMed Central: PMC6142713].
10. Khalifé M, Guigui P, Hoffmann E, Ferrero E. Techniques d'ostéotomie vertébrale. https://www em-consulte com/article/1418629/techniques-d-osteotomie-vertebrale. 2020; 20: 44-150. doi: 10.1016/S0246-0467(20)42625-X.
11. Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, Gonzalez-Moreno S, et al. A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: The results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process. Am J Surg Pathol. 2016;40(1):14-26. doi: 10.1097/PAS.0000000000000535. [PubMed: 26492181].
12. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA. Appendiceal neoplasms and pseudomyxoma peritonei: A population based study. Eur J Surg Oncol. 2008;34(2):196-201. doi: 10.1016/j.ejso.2007.04.002. [PubMed: 17524597].
13. Belhamidi MS, Zorkani Y, Krimou H, Kaoukabi A, Menfaa M, Sakit F, et al. Pseudomyxoma peritonei (PMP) secondary to mucinous carcinoma of the ovary: A case study. Pan Afr Med J. 2019;33:283. [In Persian]. doi: 10.11604/pamj.2019.33.283.17203. [PubMed: 31692896]. [PubMed Central: PMC6815498].
14. Ning S, Yang Y, Wang C, Luo F. Pseudomyxoma peritonei induced by low-grade appendiceal mucinous neoplasm accompanied by rectal cancer: A case report and literature review. BMC Surg. 2019;19(1):42. doi: 10.1186/s12893-019-0508-6. [PubMed: 31023277]. [PubMed Central: PMC6485155].
15. Prabhu RM, Koshire SR, Khandelwal RCS. A rare case of psoas abscess secondary to mucinous adenocarcinoma of the appendix: A case report. J Orthop Case Rep. 2021;11(8):1-5. doi: 10.13107/jocr.2021.v11.i08.2340. [PubMed: 35004364]. [PubMed Central: PMC8686507].
16. Ghosh RK, Somasundaram M, Ravakhah K, Hassan C. Pseudomyxoma peritonei with intrathoracic extension: A rare disease with rarer presentation from low-grade mucinous adenocarcinoma of the appendix. BMJ Case Rep. 2016;2016. doi: 10.1136/bcr-2015-211076. [PubMed: 26729823]. [PubMed Central: PMC4716424].
17. Youssef H, Newman C, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ. Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin. Dis Colon Rectum. 2011;54(3):293-9. doi: 10.1007/DCR.0b013e318202f026. [PubMed: 21304299].
18. McBride K, McFadden D, Osler T. Improved survival of patients with pseudomyxoma peritonei receiving intraperitoneal chemotherapy with cytoreductive surgery: a systematic review and meta-analysis. J Surg Res. 2013;183(1):246-52. doi: 10.1016/j.jss.2012.12.040. [PubMed: 23490141].
19. Baratti D, Kusamura S, Guaglio M, Milione M, Pietrantonio F, Cavalleri T, et al. Relapse of Pseudomyxoma peritonei after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Pattern of failure, clinical management and outcomes. Ann Surg Oncol. 2023;30(1):404-14. doi: 10.1245/s10434-022-12367-6. [PubMed: 36094689].
20. Proesmans V, Vandaele T, Van Slambrouck J, Wolthuis A, Hoore D, Dekervel J, et al. Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma. Int J Hyperthermia. 2022;39(1):1153-7. doi: 10.1080/02656736.2022.2104938. [PubMed: 36049823].
21. Pestieau SR, Esquivel J, Sugarbaker PH. Pleural extension of mucinous tumor in patients with pseudomyxoma peritonei syndrome. Ann Surg Oncol. 2000;7(3):199-203. doi: 10.1007/BF02523654. [PubMed: 10791850].
22. Sugarbaker PH, Chang D, Stuart OA. Hyperthermic intraoperative thoracoabdominal chemotherapy. Gastroenterol Res Pract. 2012;2012:623417. doi: 10.1155/2012/623417. [PubMed: 22654899]. [PubMed Central: PMC3357938].
23. Yahanda AT, Buchowski JM, Wegner AM. Treatment, complications, and outcomes of metastatic disease of the spine: From Patchell to PROMIS. Ann Transl Med. 2019;7(10):216. doi: 10.21037/atm.2019.04.83. [PubMed: 31297381]. [PubMed Central: PMC6595215].
24. Lau D, Deviren V, Ames CP. The impact of surgeon experience on perioperative complications and operative measures following thoracolumbar 3-column osteotomy for adult spinal deformity: overcoming the learning curve. J Neurosurg Spine. 2019;32(2):207-20. doi: 10.3171/2019.7.SPINE19656. [PubMed: 31653817].
| Files | ||
| Issue | Vol 10 No 3 (2024) | |
| Section | Case Report | |
| DOI | https://doi.org/10.18502/jost.v10i3.16786 | |
| Keywords | ||
| Pseudomyxoma Peritonei Disease Spine | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Huynh H, Lacroix M, Guigui P, Ferrero E, Meatchi T, KhaliféM. Pseudomyxoma Peritonei Lesion of the Thoracic Spine: A Case Report and Literature Review. J Orthop Spine Trauma. 2024;10(3):130-4.
